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drug binding, drug trapping, IC50 (50% inhibition concentration), mathematical modelling, hERG channel, action potential predictions
Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment
Hui Jia Farm
Michael Clerx
Fergus Cooper
Liudmila Polonchuk
Ken Wang
David J. Gavaghan
Chon Lok Lei
Reduction of the rapid delayed rectifier potassium current (IKr) via drug binding to the human Ether--go-go-Related Gene (hERG) channel is a well recognised mechanism that can contribute to an increased risk of Torsades de Pointes.
drug bindingdrug trappingIC50 (50% inhibition concentration)mathematical modellinghERG channelaction potential predictions
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